Tissue cross-reactivity (TCR) is a series of in vitro immunohistochemistry (IHC) screening assays used to characterize the binding of monoclonal antibodies and related antibody-like products to antigenic determinants in tissues. TCR is a very important preclinical safety study. This technology can be used to ensure that experimental antibodies or biological agents do not bind to epitopes other than the target site, and can also be used to determine target species and target organs for toxicological research.Tissue cross-reactivity (TCR) is a series of in vitro immunohistochemistry (IHC) screening assays used to characterize the binding of monoclonal antibodies and related antibody-like products to antigenic determinants in tissues. TCR is a very important preclinical safety study. This technology can be used to ensure that experimental antibodies or biological agents do not bind to epitopes other than the target site, and can also be used to determine target species and target organs for toxicological research.